Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Thalidomide 85 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCBr)C(C)(C)C)C=C1 Purity (HPLC)

85 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCBr)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

727 Purity (HPLC) >= 95% Solubility DMSO

Sulforhodamine B alkyne (Lissamine rhodamine B alkyne) is an excellent azide-reactive fluorescent reagent for labeling azide-containing biological molecules through click chemistry

29 SMILES Cl

In general

Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Thalidomide 85 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCBr)C(C)(C)C)C=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan,