Propargyl-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE bc DBCO has been extensively used

DBCO has been extensively used in copper-free click chemistry

Product Name Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C94H155N13O29 Molecular Weight 1931

S)-AHPC-CO-PEG1-C2-acid Synonyms CAS Number 2172820-07-2 Related CAS Molecular Formula C28H38N4O7S Molecular Weight 574

NCCOCCOCCOCCOCCOCCOCC(=O)NC1=CC=C2C(=O)N(CC2=C1)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-a-brac (BTB) domain of BCL6 with an IC50 of

Propargyl-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE bc DBCO has been extensively usedSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous