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Mal-Propionyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Size:25mg 937 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCCCN)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

SKU 7800669540
4.2
USD495.00 USD521.00

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Description

937 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCCCN)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

236 SMILES BrCCCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C72H95FN12O23 Molecular Weight 1515

CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCN)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Pomalidomide-5'-PEG2-propargyl Synonyms CAS Number n/a Related CAS Molecular Formula C20H21N3O6 Molecular Weight 399

Mal-Propionyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Size:25mg 937 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCCCN)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is

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