Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:5mg Product Name Thalidomide-propargyl-O-PEG2-C2-amine HCl Synonyms

Product Name Thalidomide-propargyl-O-PEG2-C2-amine HCl Synonyms Thalidomide-4'-propargyl-O-PEG2-C2-amine HCl CAS Number n/a Related CAS Molecular Formula C22H26ClN3O7 Molecular Weight 479

058 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Trametiglue acts as molecular glue

Permeant fluorescent probes visualize the activation of sarm1 and uncover an antineurodegenerative drug candidate

generating a strong fluorescent signal

Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Size:5mg Product Name Thalidomide-propargyl-O-PEG2-C2-amine HCl SynonymsSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage