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Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG8) ggfg S)-AHPC-CO-PEG5-C2-amine HCl Synonyms CAS Number

SKU 48102661822
4.1
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Description

S)-AHPC-CO-PEG5-C2-amine HCl Synonyms CAS Number 2375432-97-4 Related CAS Molecular Formula C35H56ClN5O9S Molecular Weight 758

336 Purity (HPLC) >= 95% Solubility DMSO

Mixed isomer of 5 and 6-FAM

BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-a-brac (BTB) domain of BCL6 with an IC50 of

448 Purity (HPLC) >= 95% Solubility DMSO

Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG8) ggfg S)-AHPC-CO-PEG5-C2-amine HCl Synonyms CAS NumberSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker

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