Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-Exatecan Size:10mg 351 SMILES CC(C)(C)OC(=O)N1CCN(CCCN)CC1 Purity (HPLC)

351 SMILES CC(C)(C)OC(=O)N1CCN(CCCN)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

523 SMILES OC(=O)CCOCCOCCOCCOCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name BODIPY labeled DCAF1 Binder Synonyms CAS Number n/a Related CAS Molecular Formula C39H43BClF5N8O3 Molecular Weight 813

894 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

The conventional maleimidocaproyl (MC) unit is replaced by Mal-Propionyl-PEG8 moiety to enhance aqueous solubility

Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-Exatecan Size:10mg 351 SMILES CC(C)(C)OC(=O)N1CCN(CCCN)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,