Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4) dbco-propionyl 495 SMILES: NCCCCC(NC(=O)C1=CC=C2C(=C1)C(=O)OC21C2=CC=C(O)C=C2OC2=C1C=CC(O)=C2)C(O)=O Purity (HPLC):

495 SMILES: NCCCCC(NC(=O)C1=CC=C2C(=C1)C(=O)OC21C2=CC=C(O)C=C2OC2=C1C=CC(O)=C2)C(O)=O Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Product Name Mal-Propionyl-PEG2-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C94H145N13O28 Molecular Weight 1905

Product Name: 5(6)-TAMRA PEG3 azide Synonyms: 5/6-Carboxytetramethylrhodamine-PEG3-Azide CAS Number: 604810-60-8 Molecular Formula: C33H38N6O7 Molecular Weight: 630

7'-dichlorofluorescein is a fluorescent intracellular pH indicator in the pH 4-5 range

Nature 2020

Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4) dbco-propionyl 495 SMILES: NCCCCC(NC(=O)C1=CC=C2C(=C1)C(=O)OC21C2=CC=C(O)C=C2OC2=C1C=CC(O)=C2)C(O)=O Purity (HPLC):SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker