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32 SMILES Cl
727 Purity (HPLC) >= 95% Solubility DMSO
82 SMILES ClC1=CC=C(NC(=O)CSC2=NN=C3C(NC4=CC=CC=C34)=N2)N=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO
677 SMILES: [O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCC#C Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only
thiol reactive CAS Number: N/A Molecular Formula: C38H46N4O6S Molecular Weight: 686
Mal-Propionyl-PEG4-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan dmea 32 SMILES ClSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent
