Propargyl-Acetyl-Val-Ala-PAB(m-PEG8)-Exatecan carboxylic acid 493 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)ON2C(=O)CCC2=O)CCN(CC(O)=O)CC1 Purity (HPLC)

493 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)ON2C(=O)CCC2=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Shipped on gel packs Storage Conditions Store at -20°C and protected from light Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

[O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCC#C Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

MaP555 mainly exists in the fluorescent zwitterion form

Product Name CP-Cy3 Synonyms SNAP2-Cy3 CAS Number Related CAS Molecular Formula C42H48ClN6O2 Molecular Weight 704

Product Name Phthalimidinoglutarimide-C3-O-PEG2-C2-amine HCl Synonyms Phthalimidinoglutarimide-4'-C3-O-PEG2-C2-amine HCl CAS Number 2138439-22-0 Related CAS Molecular Formula C22H32ClN3O6 Molecular Weight 469

Propargyl-Acetyl-Val-Ala-PAB(m-PEG8)-Exatecan carboxylic acid 493 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)ON2C(=O)CCC2=O)CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC