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a novel and potent GSPT1 degrader displaying selectivity over 9000 proteins
Cancer Research 2017
S)-AHPC-CO-PEG2-Cl Synonyms CAS Number n/a Related CAS Molecular Formula C29H41ClN4O6S Molecular Weight 609
Product Name Thalidomide-C6-OH Synonyms Thalidomide-4'-C6-OH CAS Number n/a Related CAS Molecular Formula C19H22N2O5 Molecular Weight 358
Product Name Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C49H86N10O19 Molecular Weight 1119
Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB Size:100mg a novel and potent GSPT1SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine
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